Saturday, 24 January 2015

What The Liposomal Encapsulation Means To Clinical Therapy

By Kristen Baird


The science of liposome can be traced back to mid-1960s, and is therefore considered very new in clinical medicine. Even with a lot of research and the knowledge that currently exists; this science is still in its trial stages. Liposomal encapsulation technology (LET) has been taunted as the next big thing in the clinical medicine.

Unlike other methods like in the use of needles for injections, swallowing of tablets, capsules or even syrup where the drug or the substance has to directly pass through the body tissues that are not the direct target, leading to possible reactions, loss of concentration or even interfering with the normal body functions, this method of drug administration employs an ingenious solution to drug administration. In fact, clinical trials have proven that it is better way of treating racehorses without the need of needles or syringes.

The technology uses phospholipid film or liposome to encase the desired compounds and transport them safely through the gastrointestinal tract without exposing the content to the environmental factors like the moisture, the enzymes, the salts and any other substance within body tissues. Currently, the technology has attracted other users apart from the pharmacists. The beauty product industries and the supplement industries are now turning to LET as an alternative to the conventional methods previously used for the administration of these substances into the body tissues.

Phospholipid liposome can withstand the effect of anyone radicals, especially the chemicals, the body dampness, the basic liquids, and the salts inside the digestive tract. The substance enclosed is therefore secured till it gets to the targeted tissue where the cell walls of the tissue cells open allowing the phospholipids and its content inside. The result is a superb method of drug therapy that has minimum impact to functionality of normal body system.

The effectiveness of this technology relies on the fact that liposomes easily penetrate cell walls and many other infectious biofilms, which allows for a highly effective delivery system against these pathological infections. Research has found that 5 grams of Vitamin C encased in liposomes is as effective as 50 grams of Vitamin C that is delivered intravenously demonstrating how effective this technology is in terms of delivery of compounds to the targeted tissues.

Clearly, the advantages of LET over the other forms of drug delivery are many. It allows nutrients to transport power packed natural compounds to the targeted tissues and organs without discomposing the same. This makes a lot of medical and economic sense. Normally, the drugs would be affected by a number of environmental factors as they pass to the tissues. These include oxygen, moisture, differing pH, and enzymes among others. This in addition to factors that affect absorption of nutrients into the body, such as fillers, sugars, binders, and sugar can cause a problem due to incomplete absorption.

The introduction of phospholipids into the body comes with its own merits. It eliminates serum lipids, diminishes platelet collection, cholesterol, triglyceride, and expands promotes good cholesterol. Notwithstanding this, it helps support immunity, enhances nature of memory, secures the liver and enhances one's capacity to persist exercise.

Even though the LET promises to be the most effective method of drug delivery, the old age methods such as capsules, tablets, powder forms and needles must still remain in use. These methods do not disrupt the blood flow in the system which is essential for physical fitness. Ideally, a comprehensive method that considers all the available methods would be better for any clinical therapy.




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